Accumulation of Succinate in Cardiac Ischemia Primarily Occurs via Canonical Krebs Cycle Activity
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چکیده
منابع مشابه
Krebs cycle anions in metabolic acidosis
For many years it has been apparent from estimates of the anion gap and the strong ion gap that anions of unknown identity can be generated in sepsis and shock states. Evidence is emerging that at least some of these are intermediates of the citric acid cycle. The exact source of this disturbance remains unclear, because a great many metabolic blocks and bottlenecks can disturb the anaplerotic ...
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A systematic appraisal of a large number of solvent systems was carried out for the separation of lactic, pyruvic and 3-hydroxybutyric acids and all of the KREBS cycle acids, except oxalosuccinic, using silica gel G and cellulose thin layer Chromatographie plates. Four solvent systems which allowed separation of various combinations of acids are described and the limits of this method of separa...
متن کاملEffects of Excess Succinate and Retrograde Control of Metabolite Accumulation in Yeast Tca Cycle Mutants*
METABOLITE ACCUMULATION IN YEAST TCA CYCLE MUTANTS* An-Ping Lin, Sondra L. Anderson, Karyl I. Minard, and Lee McAlister-Henn From the Department of Biochemistry University of Texas Health Science Center San Antonio, Texas 78229 Running Head: Succinate accumulation in yeast mutants *This work was supported by National Institutes of Health Grant GM051265. To whom correspondence should be addresse...
متن کاملThe Succinate - Glycine Cycle
This aminoketonic acid is the source of all the carbon atoms of protoporphyrin (2-4). In this series of reactions, t.he a-carbon atom of glycine becomes the b-carbon atom of S-aminolevulinic acid. Since the a-carbon atom of glycine, detached from its carboxyl group, is not only utilized for porphyrin synthesis but also conforms to the metabolic pattern of the “Cl” compounds (3), this carbon acy...
متن کاملcomparison of catalytic activity of heteropoly compounds in the synthesis of bis(indolyl)alkanes.
heteropoly acids (hpa) and their salts have advantages as catalysts which make them both economically and environmentally attractive, strong br?nsted acidity, exhibiting fast reversible multi-electron redox transformations under rather mild conditions, very high solubility in polar solvents, fairly high thermal stability in the solid states, and efficient oxidizing ability, so that they are imp...
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ژورنال
عنوان ژورنال: Cell Reports
سال: 2018
ISSN: 2211-1247
DOI: 10.1016/j.celrep.2018.04.104